Short answer — pick hotels with a 24/7 staffed desk, key‑card or mobile‑key access (especially to elevators), visible CCTV/onsite security, an in‑room safe, and a location in a well‑lit, busy neighborhood (Upper West/Upper East, Midtown/Chelsea, Gramercy or parts of Brooklyn/Queens like Williamsburg/Astoria). These factors matter more for solo travellers than a hotel’s marketing. (cntraveler.com)

Recommended options (mix of budget, midrange and luxury), with why they work for solo travellers:

• citizenM New York Bowery — modern, tech‑forward hotel with 24‑hour reception, key‑card access and lots of communal spaces (easy to meet people while still having secure access). Good for solo travellers who want a social but secure stay. (citizenm-new-york-bowery.us-newyorkcity.com)
• Moxy Chelsea (Marriott) — popular with younger/solo travellers; recognized by Condé Nast Traveler and offers lively public areas plus standard chain security and 24/7 staff. Good mid‑price social option in Chelsea. (prnewswire.com)
• Pod hotels (Pod 39 / Pod 51) — compact rooms priced for single travellers; many solo guests like pods for location and value. (Pod properties vary; check recent guest reviews for security/hallway access.) (thepodhotel.com)
• Freehand New York — a hybrid hostel/hotel with staffed 24‑hour reception, key‑card access and active communal spaces — great if you want social options but also secure basics. (hostelworld.com)
• Hyatt Centric Times Square (and similar major‑chain Midtown hotels) — big chains typically provide 24/7 front desk, CCTV, in‑room safes and mobile/keycard entry; staying in Midtown gives lots of foot traffic and quick transit options. Good “safe and convenient” pick. (hyatt-centric-times-square-new-york.hotelcheckout.net)
• LUMA Hotel Times Square / Luma (Times Square) — highly rated by travelers (Tripadvisor Best‑of‑the‑Best), central Midtown location and modern security/amenities — convenient if you’ll be out late. (hozpitality.com)
• The Wallace (Upper West Side) — newer boutique option on the UWS with strong guest reviews; UWS is one of the city’s quieter, well‑lit residential neighborhoods popular with solo visitors. (coffeethecanvas.com)
• The Lowell (Upper East Side, luxury) — classic luxury with concierge and doorman; good choice if you prefer maximum onsite staff and a very residential/safe feel.