Do you mean Midtown Manhattan (the main Midtown CBD around Times Square / Grand Central) or Lower Manhattan’s Financial District (Wall Street / World Trade Center)? Both are major “central business” areas in NYC — I’ve listed good hotel options near each below (luxury → budget-ish), with addresses and why they’re convenient for business travel.

Midtown (Midtown Manhattan — Times Square / Grand Central / Rockefeller Center)

• Hyatt Grand Central New York — 109 E 42nd St. Adjoins Grand Central Terminal (excellent subway and commuter-rail connections), good for meetings across Midtown and fast access to airports via Grand Central/LIRR. (en.wikipedia.org)
• New York Marriott Marquis — 1535 Broadway (Times Square). Large meeting/banquet capacity, very central for Midtown offices and theaters; easy access to multiple subway lines. (marriott.com)
• Park Hyatt New York — 153 W 57th St (near Carnegie Hall / Central Park South). Upscale property with quieter luxury rooms near Midtown corporate addresses (good if you want a premium stay near business hubs). (parksleephotels.com)
• The Langham, New York, Fifth Avenue — 400 5th Ave. Luxury option on Fifth Avenue with fast access to Midtown East/West offices and Bryant Park. (langhamhotels.com)

Lower Manhattan / Financial District (Wall Street, One World Trade Center, Brookfield Place)

• Conrad New York Downtown — 102 North End Ave (Battery Park City area). All-suite luxury hotel near Brookfield Place, short walk to WTC/FiDi offices and PATH/ferry options. (hilton.com)
• Millennium Downtown New York — 55 Church St. Large hotel directly across from the World Trade Center / Oculus — convenient for Financial District meetings and the PATH/subway hub. (millenniumhotels.com)
• The Beekman, a Thompson Hotel — (Nassau St / near the Brooklyn Bridge). Upscale, historic-property choice within easy walking distance of Wall Street and the 9/11 memorial area. (thebeekman.com)
• Hyatt Centric Wall Street (formerly Andaz Wall Street) — 75 Wall St. Modern, well-located in the Financial District close to NYSE, subway lines, and ferries. (chamberofcommerce.com)

Quick tips

• If your meetings are clustered in Midtown, pick a Midtown hotel (Grand Central / Times Square gives the most central access). If they’re in Lower Manhattan, choose a FiDi hotel to minimize commute/time lost.
• For fastest airport access: Midtown hotels near Grand Central are best for LIRR to/from JFK; Lower Manhattan hotels have easier access to Staten Island/Battery Park ferries and PATH trains to NJ. (Check specific transit schedules for your travel dates.)
• I can narrow these by your budget, exact neighborhood (Midtown East vs. Times Square vs. FiDi), required amenities (large meeting rooms, executive lounge, gym), or specific dates — tell me any preferences and I’ll pick the best matches and current rates/availability.

Would you like me to show availability and current prices for any of these hotels for particular dates?