Great — here are top New York City hotels well suited to hosting business conferences, grouped by the kind of meeting they excel at. For each I note why it’s a fit plus key meeting-space numbers (capacity / total meeting sq ft) so you can compare quickly.

Big, convention-scale (large plenaries, hundreds–thousands)

• New York Marriott Marquis (Times Square) — massive, flexible meeting inventory and multiple ballrooms; ideal for large plenary + many breakout rooms. Total meeting space ~100–110k+ sq ft; largest ballrooms seat up to ~2,400–2,800. (cvent.com)
• New York Hilton Midtown — one of the largest hotel meeting footprints in NYC with ~150,000 sq ft of event space and ballrooms that support multi-thousand-person functions; strong in banquet/large-meeting logistics. (hilton.com)
• Sheraton New York Times Square — large, renovated conference center with ~60k sq ft of flexible space and ballrooms that handle ~1,200–2,800 guests depending on configuration; good for big meetings in Times Square. (cvent.com)
• Grand Hyatt New York (across from Grand Central) — ~60,000+ sq ft of meeting space, excellent transit access for attendees arriving by rail; good mix of large and mid-size rooms. (revelr.com)

Mid-size / high-capacity (multi-track conferences, trade shows with smaller footprints)

• The Westin New York at Times Square — ~28k–29k sq ft meeting space with ballrooms in the 3k+ sq ft range; centrally located for Midtown events and well suited for multi-track conferences of a few hundred. (marriott.com)
• InterContinental New York Times Square — dedicated meeting floor and pillar-free Gotham Ballroom (~4,000 sq ft) plus several breakout rooms; good for executive conferences and mid-size meetings in Times Square. (ihg.com)
• Kimpton Hotel Eventi — ~20k–30k sq ft of flexible indoor/outdoor meeting space (ballroom ~4,000 sq ft), creative/tech-forward setups and outdoor terrace options — great for marketing/product events and receptions. (hoteleventi.com)

Luxury / executive & boutique (board meetings, C-suite off-sites, private conferences)

• Four Seasons Hotel New York Downtown — boutique-but-capable meeting floor, ~6,800 sq ft total, strong on privacy, hybrid event support and high-touch service. Good for board-level programs and executive retreats. (fourseasons.com)
• Mandarin Oriental, New York — large, daylight-filled ballroom (~6,000 sq ft) and premium AV/service; excellent for high-profile executive events with spectacular views. (mandarinoriental.com)
• The Peninsula New York — intimate collection of refurbished function rooms (~3,300 sq ft total) suited to small executive conferences, VIP receptions and high-touch hospitality. (peninsula.com)

Quick selection guide (which to pick)

• If you need the largest single-room capacity or 30+ simultaneous breakout rooms → Marriott Marquis, Hilton Midtown, Sheraton. (cvent.com)
• If transit access (Grand Central / Penn Station) matters most → Grand Hyatt (across Grand Central) or hotels near Penn/Times Square. (revelr.com)
• If you want a high-end, private executive experience with premium rooms and service → Four Seasons, Mandarin Oriental, Peninsula. (fourseasons.com)
• If you want creative/tech-forward spaces (outdoor terraces, multimedia screens) → Kimpton Eventi. (hoteleventi.com)

Practical tips for booking NYC hotel conferences

• Block rooms and secure meeting space early (12–18 months for very large events, 6–12 months for mid-size) — NYC inventory fills quickly.
• Confirm on-site AV & hybrid-event partners in writing (bandwidth, dedicated tech staff, streaming/backups).
• Compare total event cost (room rental + F&B minimums + AV + service charges + labor) rather than headline rental alone.
  (These are standard industry best practices — hotel event pages above list AV/planning services for each property.) (marriott.com