Short answer: sometimes — many online casinos do accept credit cards (Visa and Mastercard most commonly), but it depends on the casino, the payment processor they use, and the laws in your country or state.

Key points to know:

• Which cards: Visa and Mastercard are the most widely accepted. AmEx and Discover are accepted less often.
• Geographic and legal limits: Online gambling is illegal or restricted in some jurisdictions; even if a website accepts cards, banks or card networks may block gambling transactions in places where it’s prohibited.
• Bank/card blocks: Some banks or credit-card issuers block gambling or flag it as a risky merchant. If a card is declined, it may be the issuer, not the casino.
• Cash-advance treatment: Some issuers treat gambling deposits as cash advances — that can mean immediate interest and extra fees. Check with your card issuer.
• Verification and limits: Expect identity and age verification, deposit limits, and possible hold times for large withdrawals.
• Fees & processing time: Deposits with cards are usually instant; withdrawals rarely go back to a credit card (casinos often require bank transfers, e-wallets or checks for payouts), and withdrawal times vary.
• Safer alternatives: e-wallets (PayPal, Neteller, Skrill), prepaid cards, bank transfers, and cryptocurrencies are commonly offered and sometimes more convenient for payouts.

Practical steps:

1. Check the casino’s payments page and T&Cs to see accepted cards and withdrawal methods.
2. Check legal status of online gambling where you live.
3. Confirm with your card issuer whether they allow gambling transactions and whether they treat them as cash advances.
4. Use licensed/reputable casinos and enable responsible-gambling protections.

If you want, tell me your country or state and I can check whether online casinos commonly accept credit cards there and point out legal considerations.