Short answer — there’s no single “safe” online casino that works everywhere in the U.S. The safest option is always a regulated, state‑licensed operator that’s available in your state. Major, generally trustworthy brands that operate licensed iCasino products in U.S. states (where online casino play is legal) include:

• BetMGM Casino (licensed in MI, NJ, PA, WV). (casino.BetMGM.com)
• DraftKings Casino (licensed in CT, MI, NJ, PA, WV). (sportingpost.com)
• FanDuel Casino (licensed in NJ, PA, MI, WV, CT). (gamingtoday.com)
• Caesars / Harrah’s online casinos (widely licensed where iGaming exists — check state list on Caesars’ site). (See state licensing notes under Caesars’ regulatory pages and state regulators.) (gamingtoday.com)

Why these are considered safer

• They operate under state gaming regulators (NJ Division of Gaming Enforcement, Michigan Gaming Control Board, Pennsylvania Gaming Control Board, etc.), which impose audits, consumer‑fund protections, and player dispute processes. (casino.BetMGM.com)
• They use geolocation, age verification, AML/KYC, audited RNGs and widely used payment processors (PayPal, bank transfer, cards) so deposits/withdrawals are traceable and regulated. (GAD.bet)

Important safety checklist (use before signing up)

• Confirm the site is licensed in your specific state (regulators’ pages or the casino’s “Where we operate” / licensing page). If it’s not licensed, don’t play. (sportingpost.com)
• Look for regulator seals (NJ DGE, PGCB, MGCB, WV Lottery, CT DCP) and license details in the footer. (casino.BetMGM.com)
• Check for SSL (https), audited RNGs (e.g., eCOGRA, iTech Labs mentions), clear T&Cs and payout/withdrawal policies. (gamingtoday.com)
• Prefer sites with reputable payment options and fast withdrawal history (player reviews & app store ratings help). (gamingtoday.com)
• Use responsible‑gambling tools (self‑exclusion, deposit limits) and confirm the site publishes those options. (ctinsider.com)

State legality reminder

• Online casino availability is state by state. Even a major brand will only permit real‑money play from inside states that have legalized iGaming (examples: NJ, MI, PA, CT, WV — but availability can change). Always confirm current state lists for the brand before you create an account or deposit. (casino.BetMGM.com)

If you’re not in a state with regulated iCasino options

• Avoid offshore/unlicensed sites — they offer little consumer protection. Consider sweepstakes casinos or social gaming alternatives that can pay prizes, or travel to a legal state if you choose to play (geolocation rules still apply). (gamingtoday.com)

If you want, tell me which state you’re in (or give permission to assume one) and I’ll list the licensed, regulated online casinos currently available there and point to the regulator pages for each.