Here are top luxury wellness resorts in Sri Lanka (excellent for Ayurveda, multi‑day wellness programmes, spa, yoga and high-end recovery). I’ve listed what each is best for, where it’s located, standout wellness offerings and a quick booking tip.

1. Santani Wellness Resort & Spa — Kandy / Central Highlands

• Best for: immersive, design‑led wellness retreats, personalised programmes (detox, stress, sleep, yoga).
• Highlights: hilltop setting, multi‑day Ayurveda and lifestyle programmes, minimal‑luxury villas and strong press acclaim/awards. (santani.com)
• Booking tip: book multi‑day packages (3–7+ nights) for the full consult + treatment plan.

2. Anantara Peace Haven Tangalle (Anantara Spa) — Tangalle / South Coast

• Best for: beachfront Ayurvedic spa programmes with resort comforts (yoga pavilion, resident Ayurvedic doctor, curated 5‑day programmes for sleep, detox, weight).
• Highlights: award‑winning Anantara Spa, tailored Ayurveda packages (Pizhichil, Shirodhara) and ocean views. (Anantara.com)
• Booking tip: ask for an Ayurvedic consultation on arrival and reserve multi‑day “Inner Harmony” or sleep programmes in advance.

3. Jetwing Ayurveda Pavilions — Negombo (close to Bandaranaike Airport)

• Best for: dedicated Ayurvedic retreat with resident Ayurvedic doctors and authentic treatment regimens (Panchakarma etc.).
• Highlights: purpose‑built Ayurveda therapy centres, on‑site Ayurveda pharmacy, dosha‑based cuisine and private pavilions for treatments. (jetwinghotels.com)
• Booking tip: ideal for travellers wanting to begin or finish a Sri Lanka trip with authentic Ayurveda (short transfer from the airport).

4. Cape Weligama (Resplendent Ceylon) — Weligama / South Coast

• Best for: luxury seaside wellness with spa, tea‑inspired treatments and activity programmes (yoga, fitness camps, surf + yoga).
• Highlights: boutique luxury villas, Tea‑inspired spa treatments (partnered products), wellness and fitness programmes. (healthclubmanagement.co.uk)
• Booking tip: combine a spa programme with surf/yoga options for an active‑rest balance.

5. Ulagalla by Uga Escapes — Anuradhapura / Cultural Triangle (country estate setting)

• Best for: secluded villa‑style luxury with tailored wellness, nature walks, yoga and Ayurvedic or spa treatments in a private villa setting.
• Highlights: expansive private villas, countryside tranquillity—good for digital detox and restorative stays. (Uga Escapes property; Ulagalla is known for privacy and bespoke wellness offerings.) (niraamaya.com)

6. Sen Wellness Sanctuary (and other authentic Ayurveda retreats) — Southern coast / Weligama area

• Best for: authentic Panchakarma, specialist Ayurvedic therapies, longer detox/rehab programmes in a dedicated Ayurveda centre.
• Highlights: focused medical Ayurveda programmes (Panchakarma, long‑course detox), nature‑based settings and specialist therapists. (senwellnesssanctuary.com)
• Booking tip: plan 10–21 days if you want full Panchakarma; do a pre‑stay medical consultation.

7. Barberyn (Barberyn Beach Ayurveda Resort) — Weligama / Southern coast (partner option)

• Best for: traditional Sri Lankan Ayurveda led by experienced Ayurvedic doctors and therapists; often paired with neighbouring luxury hotels for comfort.
• Highlights: long history as an Ayurveda centre; many high‑end hotels (e.g., Cape Weligama) arrange Barberyn consultations and therapies. (birdtravelpr.com)

Notes on choosing the right resort

• If you want medically supervised Panchakarma or a clinically oriented Ayurvedic cure, choose a dedicated Ayurveda centre or a resort with resident Ayurvedic doctors (Jetwing Ayurveda Pavilions, Barberyn, Sen). (jetwinghotels.com)
• For a luxury design‑forward wellness retreat (minimalist architecture + tailored lifestyle programmes), Santani is a standout. (santani.com)
• For beach + spa + variety of programmes (yoga, fitness, Ayurveda tasters), southern coast resorts like Anantara Peace Haven, Cape Weligama and Weligama wellness centres are excellent. (Anantara.com)

Practical tips

• Length: Ayurvedic and detox programmes are most effective over multiple days (3–14+). Full Panchakarma commonly requires 10–21 days. (jetwinghotels.com)
• Medical: tell the resort about medications/health conditions before arrival; many resorts require an initial medical consultation with an Ayurvedic doctor. (jetwinghotels.com)
• Transfers: southern coast resorts are ~3–4 hours from Bandaranaike (Colombo) airport; Negombo is closest to the airport. Schedule arrival/departure days around treatment plans. (Anantara.com)

Want me to:

• Narrow this to the top 3 by category (best for Ayurveda, best for luxury wellness design, best beachfront spa), or
• Check current availability/rates for specific dates and bookable packages at any of these properties?