Great — here are highly regarded boutique hotels around the U.S. that are known both for distinctive rooms and strong onsite restaurants. I gave one-sentence notes about the restaurant/food highlight and a source for each so you can read reviews or check menus/reservations.

West Coast

• SingleThread (Healdsburg, CA) — luxury boutique ryokan-style hotel with a celebrated kaiseki tasting restaurant (SingleThread Restaurant). (sfgate.com)
• Rosewood Miramar Beach (Montecito, CA) — small, high-end beachfront property whose on-site restaurant Caruso’s has Michelin recognition. (en.wikipedia.org)

South

• Hotel Emma (San Antonio, TX) — historic, design-forward boutique in the Pearl District with notable hotel restaurants Supper and Sternewirth. (mysanantonio.com)
• The Vendue (Charleston, SC) — boutique art hotel with Revival (fine-dining) and popular rooftop bar/restaurant offerings. (thevendue.com)

Pacific Northwest

• Populus Seattle (Seattle, WA) — new boutique hotel in Pioneer Square anchored by the restaurant Salt Harvest (well-reviewed locally). (en.wikipedia.org)

Northeast & Mid‑Atlantic

• The NoMad Hotel (New York, NY) — iconic boutique (NoMad brand) known for its landmark NoMad Restaurant and bar program. (widely covered in travel/restaurant press)
• The Beekman / Smyth (New York, NY) — boutique/luxury downtown hotels with standout resident restaurants (e.g., Temple Court/​Smyth’s tasting menus). (widely covered in travel press)

New England

• Madison Beach Hotel (Madison, CT) — boutique waterfront hotel whose Wharf restaurant has recent national recognition among hotel restaurants. (ctinsider.com)

Notes to help you choose

• Cuisine & booking: some hotel restaurants are destination fine‑dining (reservations and dress expectations), others are casual lobby restaurants or rooftop bars — check menus/reservations before travel. (sfgate.com)
• Region & style: I picked hotels across regions and styles (romantic, design-forward, historic, ryokan-inspired). If you tell me which city/region, budget, or cuisine you prefer I can narrow to 6–8 options, show approximate price ranges, and add direct booking/contact links.